Category Archives: Health

THE CURIOSITY CURE

From Darwin’s worms to Turner’s sunsets, why wonder may be the last great art of growing old.

By Michael Cummins, Editor, September 4, 2025

The rehearsal for memory begins with a question. Where on earth do trees grow with square trunks? It sounds like a riddle from a child’s notebook or a surrealist painting. And it is the question that opened a recent episode of The Guardian’s Science Weekly podcast. The scientists on the program did not answer right away. They made us wait. And that pause, that stretch of uncertainty, is the secret heart of curiosity—the ache that sharpens the mind. To age well, perhaps, is not to gather the answers, but to continue cultivating that ache.

Consider the way a child treats the world. A blurred photograph, a half-said phrase, a dinosaur’s unpronounceable name—all of these are invitations to wonder. Researchers like Dr. Matthias Gruber and Dr. Mary Watley have made a career out of studying that impulse, and what they’ve found is both simple and astonishing. Curiosity—when we let it run its course—lights up the reward circuits of the brain. The hippocampus stirs awake. Memory forms like clay pressed to the mold of desire. The moment of anticipation, the leaning forward in one’s chair before the answer drops—that is where learning becomes not a duty but a joy.

It sounds obvious in theory, yet how often do we short-circuit it? A conversation stalls on a forgotten film title and within seconds a phone flashes the answer. We no longer linger in the sweet spot where knowledge is almost, but not quite, in reach. We save ourselves from the discomfort of not knowing, and in the process, we cheat ourselves of the neurological reward. As Jordan Litman writes in The Curiosity Effect, “we rob ourselves of the very thing that makes knowledge memorable when we outsource every answer to a device.” One study found that people would rather sit with a question, guessing and fumbling, than have the answer immediately revealed. The waiting was the pleasure. In a culture allergic to delay, what are we losing by satisfying every flicker of curiosity instantly?

The story deepens when curiosity is followed across a lifespan. As children, we are indiscriminate: we want to touch, taste, and know everything. By the time we hit our forties, something constricts. The world presses in—mortgages, children, aging parents, bosses, and deadlines—and curiosity, broad and restless, shrinks to a pinhole. This is the curious paradox: we are at our least curious precisely when we are most in need of escape. In middle age, to wonder feels like a luxury. Yet in the later decades, curiosity resurges, not in breadth but in depth. Watley and colleagues, in their 2025 study Curiosity Across the Adult Lifespan, found that while trait curiosity—the stable appetite for knowledge—declines with age, state curiosity, or situational bursts of interest, actually increases in older adults. “We are not less curious with age,” they write, “but differently curious.”

The arc of curiosity across life resembles a river: wide at the source, narrowed by the rocks of midlife, widening again as it approaches the sea. Sakaki, Yagi, and Murayama argue in Curiosity in Old Age: A Possible Key to Achieving Adaptive Aging that this narrowing and widening reflects the brain’s flexibility itself: “Curiosity serves as a dynamic coping resource, allowing older adults to adapt cognitively and emotionally to the challenges of aging.” To age with curiosity is not simply to preserve information, but to practice resilience.

Wallace Stevens sensed this:

Death is the mother of beauty. Only the perishable can be beautiful…

Aging, in his vision, is not decline but the condition of wonder itself. We perceive beauty because we know it vanishes. Curiosity, then, is a metaphysical defiance, a way of leaning into what slips away. Wallace Stevens also reminds us:

Reality is a cliché from which we escape by metaphor.

For the aging mind, curiosity is the metaphorical escape hatch, a refusal to let life calcify into cliché.

Why does it matter? Because curiosity, more than any supplement or crossword puzzle, appears to be a quiet ally against cognitive decline. Those who sustain trait curiosity—the broad hunger for new things—show stronger “cognitive reserve,” the brain’s ability to withstand the slow bruises of age. As Gene Cohen put it in The Aging Brain, “curiosity is not a byproduct of youth; it is a neuroprotective force, a way the brain rehearses its own adaptability.” Cohen’s case studies tell of octogenarians who take up painting, learn Mandarin, or dive into family genealogy not for professional gain, but for sheer, stubborn delight. Their curiosity does not erase aging; it rewrites its script.

Charles Darwin understood this in his final decades. Long after the voyage of the Beagle and the storm of On the Origin of Species, he retreated to Down House, weakened by chronic illness yet still possessed by restlessness. His notebooks from his seventies reveal obsessions not with grand evolutionary arcs but with the behavior of earthworms, how they swallowed soil, turned fields, altered the landscape. Many mocked these studies as trivial. Darwin did not. To him, worms were a final frontier, a slow curiosity about the smallest architects of the earth. He dug into soil and into age itself, confirming what Paul Celan would later crystallize in poetry:

There was earth inside them, and they dug.

Darwin’s late life curiosity was not about conquest but about humility, the patience to follow small questions wherever they led.

So too with Michelangelo, whose last sculptures—the unfinished Rondanini Pietà—show the great master chipping away at marble almost until the day he died at eighty-eight. Gone were the muscular certainties of his youth. What remained was a restless, trembling exploration of form dissolving into spirit. Figures blur, limbs elongate, stone seems to sigh. This was curiosity turned inward, the artist asking: what remains when mastery fades? It was less triumph than question—curiosity as chiseling into mystery itself.

And then J.M.W. Turner, nearly blind, staggering into the London fog of his late years. His paintings in the 1840s dissolve into storms of light and color—Rain, Steam and Speed, the Sea Battles, his almost abstract sunsets. Critics scoffed that he had lost his way. But Turner’s late canvases were curiosity made incandescent: a refusal to paint what he had already mastered, a hunger to see how light itself might undo form.

Turner’s brushstrokes became metaphors for perception itself, daring us to see the world not as fact but as possibility.

But curiosity does more than keep the brain agile—it preserves identity. In their research on learning among older adults, Kim and Merriam discovered that curiosity is inseparable from purpose. “Older learners do not learn to pass time,” they note. “They learn to affirm who they are becoming.” Susan Krauss Whitbourne echoes this in Curiosity and the Aging Self: “Curiosity allows older adults to stitch together continuity and change, to make meaning of both what has been and what is still possible.” To be curious in later life is to declare: I am not finished. Rilke, in Letters to a Young Poet, insists:

The future enters into us, in order to transform itself in us, long before it happens.

Curiosity in age is not nostalgia but preparation—the invisible pressing inward, asking us still to change. Or, in his famous imperative:

You must change your life.

Of course, the dark side cannot be ignored. Curiosity lures us not only toward symphonies and languages but toward car crashes and scams. Morbid curiosity is what slows traffic by the wreck. Online, it is the bait behind headlines—You won’t believe what happens next—that seduces us into click after click. For older adults, whose craving for resolution may make them less discerning, curiosity can become a liability, leaving them vulnerable to fraud and misinformation. As the Innovative Aging time-sampling study revealed, curiosity in older adults fluctuates with anxiety: high levels of uncertainty can sharpen curiosity, but they can also corrode judgment. “The desire to resolve tension,” the study concludes, “can make older adults more vulnerable to accepting simple but false answers.”

Still, to dismiss curiosity for its risks would be to dismiss fire for its burns. The great artists and thinkers carried it as both burden and gift. Goethe, scribbling in his eighties, remained restless as a student. Toni Morrison published novels when most of her peers were content with memory alone. Frank Lloyd Wright designed the Guggenheim Museum at ninety. Their curiosity was not a refusal to age, but a way of ageing differently—turning each year into another aperture rather than another wall. T.S. Eliot gave it a timeless formulation:

Old men ought to be explorers.

And in his final Quartet:

We shall not cease from exploration
And the end of all our exploring
Will be to arrive where we started
And know the place for the first time.

Curiosity does not deny mortality; it loops us back to origins, reframed by age.

Paul Celan’s fractured lyricism captures the moral weight of this work:

Speak, you too, speak as the last, have your say.

In old age, curiosity is no longer optional—it is the last duty, to remain open, to refuse silence.

One elderly woman, at ninety-one, could often be found hunched at her kitchen table, teaching herself Spanish verbs from a battered paperback workbook. She would never travel to Madrid or Mexico City. She was not chasing utility. She wanted the taste of a new language in her mouth, the satisfaction of puzzle and pattern. When she forgot the word for door in English, she would still smile at having remembered puerta. Her curiosity was not a guard against ageing; it was ageing done with grace. Her curiosity, like what Sakaki and Murayama call a “proxy for adaptive aging,” became her measure of resilience, even in decline.

Curiosity is also spiritual hunger. John Donne, caught in his paradoxes, reminds us:

Be thine own palace, or the world’s thy jail.

To age without curiosity is to dwell in the jail of repetition; to age with it is to build palaces of interior richness. And in the Holy Sonnets, he whispers across centuries:

When thou hast done, thou hast not done, for I have more.

Curiosity ensures that even at the edge of life, there is always more.

So is curiosity the key to ageing well? The podcast hedged. Scientists prefer caution. Yet what their data suggested was less a key than a posture, a way of leaning into the world. Curiosity keeps us not young, but alive to the present. It prevents the slide into cynicism, the sense that we already know what the day will bring. To be curious is to keep finding the world strange and therefore worth waking up to. Or as Whitbourne writes, “Curiosity is the stubborn insistence that the story isn’t over yet.” Stevens, Eliot, Rilke, Donne, Celan—they all converged on the same truth: curiosity in age is not ornament but essence.

The riddle that opened the podcast lingered across the episode like a withheld gift. Where do trees grow with square trunks? Not here, not in the daily landscape we take for granted. They grow in Panama’s Anton’s Valley, a reminder that the world still offers unlikely geometries if we are willing to ask. Perhaps that is the true answer: curiosity does not smooth the years or extend the clock. It gives us square trees in a round world, a glimpse of wonder tucked inside the ordinary. And maybe that glimpse is enough.

THIS ESSAY WAS WRITTEN AND EDITED UTILIZING AI

HEALTHY AGING: WHY LEAN MUSCLE MASS IS ESSENTIAL

By Michael Cummins, Editor

When we envision the journey of aging, we often focus on the more visible signs—the lines on our faces, the graying hair, or the occasional ache in our joints. But the most profound changes occur beneath the surface, particularly within our muscular system. The gradual loss of muscle mass, a condition known as sarcopenia, is often accepted as an inevitable part of getting older. Yet, this decline is far from a cosmetic concern. It represents a fundamental shift in our body’s operating system, compromising our resilience and making us more vulnerable to chronic disease.

Modern science has revolutionized our understanding of skeletal muscle. It is not merely a tool for movement but a dynamic, multifaceted endocrine organ—a bustling chemical factory that profoundly influences every aspect of our health. By actively engaging and maintaining this “factory,” we can effectively fight back against the aging process at a cellular and systemic level. This essay will explore the critical importance of preserving lean muscle mass, detailing its key functions in regulating metabolism, combating chronic inflammation, bolstering our immune system, and acting as a protective shield for the entire body. Ultimately, it will argue that building and maintaining muscle should be a foundational and non-negotiable pillar of any strategy for promoting a long, healthy, and vibrant life.

The Unseen Architects: A Deeper Look at Mitochondria

To truly appreciate the power of muscle, we must first look inside the cell at the microscopic architects that make it all possible: the mitochondria. While famously known as the “powerhouses” of the cell, their story is far more fascinating. As scientist Lena Pernas from the Max Planck Institute for Biology of Ageing explains in her TEDxPadova talk, their ancestors were ancient bacteria that, over 1.5 billion years ago, forged a symbiotic relationship with our early eukaryotic ancestors by finding their way into a larger cell and staying. This remarkable evolutionary event is why mitochondria still retain some bacterial traits, including their own unique circular DNA, known as mtDNA. Interestingly, all of our mitochondrial DNA is passed down exclusively from our mothers.

“To truly appreciate the power of muscle, we must first look inside the cell at the microscopic architects that make it all possible: the mitochondria.”

These tiny organelles are responsible for converting the oxygen we breathe and the nutrients we consume into adenosine triphosphate (ATP), the chemical energy that powers our every thought, movement, and biological process. Mitochondria are not scattered randomly in our bodies; they are strategically placed in the greatest numbers and size within the tissues that have the highest energy demands. This makes our lean muscle tissue a prime location for these cellular power plants. A healthy, active muscle is packed with a dense network of mitochondria, ready to produce the vast amounts of energy needed for physical activity. The strength and efficiency of this mitochondrial network are directly linked to the health and vitality of your muscles, making the connection between muscle mass and healthy aging all the more profound.

The Metabolic Engine Room: Regulating Your Body’s Energy

Skeletal muscle is the single largest organ in the human body, constituting nearly 50% of total body weight in a lean individual. Its sheer size and constant activity make it a metabolic powerhouse. One of its most vital roles is as the body’s primary glucose regulator. After a meal, muscle tissue acts as a massive storage container, efficiently taking up glucose from the bloodstream in response to insulin’s signal. This action is crucial for keeping blood sugar levels balanced and preventing the dangerous spikes and crashes associated with metabolic dysfunction.

“By maintaining a robust amount of muscle mass, you effectively protect this system, keeping your metabolic ‘engine room’ running smoothly.”

However, as we age and lose muscle mass, this storage container shrinks. The remaining cells have to work harder to manage blood sugar, which often leads to a condition called insulin resistance. In this state, your body’s cells become less responsive to insulin’s message, causing glucose to accumulate in the bloodstream—a key precursor to Type 2 diabetes. Insulin resistance triggers a dangerous cascade of events. The excess glucose in the blood can bind to proteins, forming pro-inflammatory molecules known as Advanced Glycation End-products (AGEs).

Additionally, impaired insulin action leads to a rise in circulating free fatty acids, which directly activate inflammatory pathways within cells. This vicious cycle, where metabolic dysfunction drives inflammation and vice versa, is a cornerstone of numerous age-related diseases. By maintaining a robust amount of muscle mass, you effectively protect this system, keeping your metabolic “engine room” running smoothly and providing a high-leverage strategy for preventing chronic conditions.

Fighting Inflammation: Your Body’s Internal Anti-Inflammatory Factory

Chronic, low-grade systemic inflammation is a major driver of age-related decline. Known as inflammaging, this slow-burning inflammatory state contributes to everything from heart disease and arthritis to neurodegenerative disorders. The genius of skeletal muscle lies in its ability to actively combat this process.

When muscles contract during physical activity, they release a complex cocktail of signaling molecules called myokines. These myokines act as powerful, natural anti-inflammatory agents. They are the chemical messengers of your muscle’s “pharmacy,” traveling throughout the body to modulate inflammatory and immune responses. Without enough muscle and physical activity, you lose this natural defense, allowing the chronic inflammatory “fire” to burn hotter.

One of the most well-studied myokines, Interleukin-6 (IL-6), beautifully illustrates this concept. While often associated with inflammation in its chronic state, when it is secreted acutely by working muscles, it acts as a powerful anti-inflammatory signal. Muscle-derived IL-6 can inhibit the production of other pro-inflammatory cytokines, creating a more balanced and healthy systemic environment.

Brown Fat: Your Body’s Calorie-Burning Furnace

A particularly exciting and potent anti-inflammatory function of myokines is their ability to influence your body’s fat tissue. Not all fat is created equal. While white fat stores energy, brown fat is a specialized tissue packed with mitochondria that burns calories to produce heat. People with higher levels of brown fat are often at a lower risk for conditions like type 2 diabetes and heart disease, even if they are overweight.

“By keeping your muscles active, you are sending out potent signals that actively work to counteract the systemic inflammation and metabolic dysfunction that drives the aging process.”

Skeletal muscle plays a vital, direct role in the production and activation of this beneficial brown fat. Exercise-induced myokines, notably Irisin and Fibroblast Growth Factor 21 (FGF21), are key players in a process called “browning.” This is a remarkable biological feat where white fat cells, particularly in certain areas of the body, are signaled to transform into brown-like fat cells (often called “beige” adipocytes).

These new beige fat cells become metabolic furnaces, increasing your overall energy expenditure and helping to improve blood sugar control and cholesterol levels. By keeping your muscles active, you are not just building strength; you are sending out these potent signals that actively work to counteract the systemic inflammation and metabolic dysfunction that drives the aging process.

The Vicious Cycle: How Inactivity and Obesity Degrade Muscle

While lean muscle can act as a powerful protective agent, a sedentary lifestyle and obesity create a detrimental environment that actively degrades both mitochondrial and muscle health.

“In essence, inactivity and obesity create a vicious cycle…a dangerous cycle that accelerates the decline of overall health.”

This is a complex interplay of chronic inflammation, insulin resistance, and altered metabolic processes that forms a dangerous cycle.

Impact on Mitochondria: Inactivity and obesity are a direct assault on the cell’s powerhouses.

They impair their function by:

Reduced Mitochondrial Biogenesis: Without the stimulus of physical activity, the body suppresses the process of creating new mitochondria. This leads to a decrease in the overall number and density of these crucial power plants in your muscle cells.

Impaired Function: The existing mitochondria become less efficient at producing ATP, reducing your muscles’ capacity to generate energy.

Increased Oxidative Stress: A sedentary lifestyle and excess metabolic load lead to a significant increase in reactive oxygen species (ROS). This oxidative stress damages mitochondria and reduces your body’s natural antioxidant defenses, leading to an accumulation of cellular damage.

Compromised Quality Control: Your body has a clean-up process called mitophagy that removes damaged mitochondria. Inactivity and obesity make this process sluggish, allowing unhealthy mitochondria to build up and further compromise energy production.

Impact on Lean Muscle:
Beyond the cellular level, inactivity and obesity degrade muscle tissue through a state of chronic low-grade inflammation. This silent inflammation is a hallmark of obesity and is characterized by the infiltration of immune cells and the release of harmful molecules.

Pro-inflammatory Molecules: Immune cells and fat cells in obese individuals secrete inflammatory molecules like TNF-α and MCP-1. These molecules cause inflammation within muscle cells and interfere with their metabolism, leading to insulin resistance.

Insulin Resistance and Protein Degradation: The insulin resistance that is common with obesity directly accelerates muscle breakdown. It does this by suppressing a crucial signaling pathway responsible for building muscle protein, while simultaneously activating pathways that break down protein.

Ectopic Lipid Deposition: This is the accumulation of fat within the muscle itself, a condition known as myosteatosis. This fatty infiltration is directly linked to decreased muscle strength and a reduced ability for muscle regeneration.

In essence, inactivity and obesity create a vicious cycle. They promote chronic inflammation and insulin resistance, which in turn damages mitochondria and leads to the breakdown of muscle protein. This loss of muscle then further worsens metabolic function, fueling the cycle and accelerating the decline of overall health.

The Immune System’s Secret Fuel Tank and Guardian

Beyond their metabolic and anti-inflammatory functions, muscles are a critical support system for your immune health. The human body is a constant battlefield, and your immune cells are your first line of defense. But these cells are metabolically demanding, requiring a constant supply of energy and building blocks to function effectively. This is where lean muscle mass becomes an unsung hero.

“Think of your muscles as a vast ‘fuel tank’ for your immune system.”

Skeletal muscle is your body’s largest reservoir of protein and amino acids. This vast store is not just for building brawn; it actively provides essential amino acids for vital functions, including the rapid proliferation and activation of immune cells. A prime example is glutamine, an amino acid that is abundantly produced by skeletal muscle. Glutamine is the primary energy source for rapidly dividing immune cells like lymphocytes and monocytes. Think of your muscles as a vast “fuel tank” for your immune system.

If this tank is full, your immune cells have the fuel they need to mount a robust defense against pathogens. However, if you lose muscle mass or your body is under severe stress (such as during a serious illness), this glutamine tank can run low. When this happens, immune cells are deprived of their primary fuel source, which can compromise their function, proliferative capacity, and ability to effectively fight off infections. This direct metabolic link explains why individuals with sarcopenia or significant muscle wasting are often more susceptible to infections and have poorer outcomes when they get sick.

Beyond Strength: A Whole-Body Protective Shield

The benefits of maintaining muscle mass extend far and wide, touching virtually every system in the body. A higher lean body mass is a powerful indicator of overall health and resilience.

Bone Health: The act of resistance training creates tension on your muscles, which in turn puts a positive, mechanical stress on your bones. This stimulus signals to the bones to get stronger and denser, making resistance training one of the most effective defenses against osteoporosis.

Heart Health: A higher ratio of muscle to fat mass is associated with a healthier lipid profile, lower blood pressure, and a reduced risk of heart disease. The myokines released during exercise also play a role in protecting the cardiovascular system.

Brain Power: Research shows a fascinating link between muscle and brain health. Myokines released during exercise can have neuroprotective effects, enhancing cognitive function and potentially reducing the risk of neurodegenerative diseases. They can influence the production of brain-derived neurotrophic factor (BDNF), a molecule essential for neuronal growth and survival.

“A higher lean body mass is a powerful indicator of overall health and resilience.”

The sheer volume and metabolic activity of muscle mean that even subtle changes in its health can have widespread systemic effects, offering a powerful, protective shield for the entire body.

The Action Plan: What You Can Do

The good news is that sarcopenia is not an irreversible fate. You can actively fight muscle loss at any age, and the most effective strategy is a powerful combination of resistance training and a strategic approach to nutrition.

Resistance Training: This is the most crucial signal you can give your body to keep and build muscle. This doesn’t mean you have to become a bodybuilder; it means making your muscles work against a force. This can include:

Lifting weights: Using dumbbells, barbells, or machines.

Resistance bands: An excellent, low-impact option.

Bodyweight exercises: Squats, lunges, push-ups, and planks are highly effective.
The key is progressive overload, which means gradually increasing the intensity over time to challenge your muscles and force them to adapt and grow.

Eating Enough Protein: Protein is the essential building block of muscle tissue. As we get older, our bodies become less efficient at using protein, a phenomenon called “anabolic resistance.” This means older adults need a higher intake of protein per meal than younger individuals to achieve the same muscle-building response. Aim for a consistent intake of high-quality protein with every meal, especially around your resistance training sessions, to maximize muscle protein synthesis and counteract sarcopenia.

Crucially, the research shows that combining these two strategies—exercise and nutrition—creates a synergistic effect. The benefits are amplified when you support your muscles with both the mechanical stimulus to grow and the nutritional building blocks they need.

Conclusion

The journey of healthy aging is not about avoiding the passage of time but about building a body that can withstand its effects. At the heart of this process lies our skeletal muscle. By moving beyond the old paradigm of muscle as a simple locomotive tool, we can appreciate its central and multifaceted role as a metabolic regulator, an anti-inflammatory agent, and a vital supporter of our immune system. The progressive loss of this powerful organ is a primary driver of age-related decline and chronic disease.

“The secret to a long, healthy life isn’t hidden in a mythical fountain of youth—it’s waiting for you to build it, one muscle fiber at a time.”

However, this new understanding also provides a clear and empowering path forward. By prioritizing regular resistance training and a thoughtful approach to nutrition, we can actively build and maintain our lean muscle mass. This is not just an investment in a stronger body; it is an investment in a more resilient metabolism, a calmer inflammatory system, and a more robust immune defense. The secret to a long, healthy life isn’t hidden in a mythical fountain of youth—it’s waiting for you to build it, one muscle fiber at a time.

THIS ESSAY WAS WRITTEN AND EDITED UTILIZING AI